The internal cleanliness, chemical stability, air tightness and biological properties of chlorobutyl rubber stopper material are very good, but due to the complex formulation and the concentration gradient of the added raw materials, after encapsulation with some drugs with strong molecular activity, they are absorbed by the drug. , adsorption, leaching, penetration, resulting in the compatibility of rubber plugs and drugs, the more prominent are some cephalosporins, some large infusions, and many traditional Chinese medicine injection preparations.

Therefore, by choosing an inert soft coating (film-coated material) to cover the surface of the rubber stopper to isolate the direct contact between the medicine and the rubber stopper, the compatibility with the medicine can be significantly improved. After the chlorobutyl rubber stopper material is coated, it can effectively reduce the absorption, adsorption, leaching and penetration between the rubber stopper and the drug, improve the long-term stability of the drug, improve the mechanical lubricity of the rubber stopper, and greatly reduce the insolubility of the drug solution caused by silicone oil. An increase in the number of particles.